In a medium skillet cook bacon, sausage, onions, bell peppers and mushrooms over medium heat until onions are translucent and peppers are soft, about 3-4 minutes. Add pepperoni slices. Remove from heat.
Divide bread dough in 4 equal pieces. Roll out into a circle on a floured board.
Spread tomato sauce over each circle leaving ½ inch around the outer edge.
Divide topping equally between the circles, placing it on half of the circle only. Divide the cheese evenly between the circles.
Wet the outer edge of each circle and fold the half without topping over the half with topping Use a fork to press down the edges.
Use a spatula to move each calzone to a baking sheet.
Bake at 375° F. until golden brown, about 10-15 minutes.